FABPs ligand 6

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FABPs ligand 6 (MF6) 是一种 FABP5 和 FABP7 抑制剂，KD 值分别为 874 nM 和 20 nM。FABPs ligand 6 可用于多发性硬化症的研究。

FABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with KD values of 874 nM and 20 nM, respectively. FABPs ligand 6 can be used for multiple sclerosis research.

FABPs ligand 6 (MF6) rescues mitochondrial function by blocking voltagedependent anion channel (VDAC)-1-dependent mitochondrial macropore formation induced by psychosine in KG-1C cells, a FABP5- mediated injury.

MF 6 (1 mg/kg; i.g.; daily for 4 weeks) improves the severity of EAE (experimental autoimmune encephalomyelitis) and attenuates oxidative levels and the inflammatory response.Animal Model:8-10-week-old female C57BMF/6J mice with MOG35-55-administered experimental autoimmune encephalomyelitis (EAE) mouse model Dosage:1 mg/kg Administration:Intragastric administration, daily for 4 weeks Result:Attenuated EAE symptoms, decreased oxidative stress, inhibited astrocyte activation and protected oligodendrocytes.

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Membrane Transporter/Ion Channel

FABP

FABP

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2988135-14-2

458.52

C28H27FN2O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (272.62 mM; 超声助溶 )

O=C(O)CCCOC=1C=CC(F)=CC1C2=NN(C3=CC=C(C=C3)C(C)C)C(=C2)C=4C=CC=CC4

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(-20℃)

With Ice Pack

≥ 2 years